Cargando…

Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of α-Helical Membrane-Active Peptides

V13K, a 26-residue peptide, has been shown to have strong antimicrobial activity, negligible hemolytic activity, and significant anticancer activity. In the present work, V13K was used as the framework to investigate the influence of helicity, as influenced by d-amino acid substitutions in the cente...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Shiyu, Zhao, Guangxu, Huang, Yibing, Cai, Mingjun, Yan, Qiuyan, Wang, Hongda, Chen, Yuxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796017/ https://www.ncbi.nlm.nih.gov/pubmed/29280948 http://dx.doi.org/10.3390/ijms19010067

Ejemplares similares

Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy
por: Sun, Shiyu, et al.
Publicado: (2016)

Prokaryotic expression and mechanism of action of α-helical antimicrobial peptide A20L using fusion tags
por: Yi, Tonghui, et al.
Publicado: (2015)

Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria
por: Tan, Juanjuan, et al.
Publicado: (2014)

Role of helicity of α-helical antimicrobial peptides to improve specificity
por: Huang, Yibing, et al.
Publicado: (2014)

Tryptophan as a Probe to Study the Anticancer Mechanism of Action and Specificity of α-Helical Anticancer Peptides
por: Li, Guirong, et al.
Publicado: (2014)

TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy
por: Hao, Xueyu, et al.
Publicado: (2015)

Two hits are better than one: synergistic anticancer activity of α-helical peptides and doxorubicin/epirubicin
por: Zhao, Jing, et al.
Publicado: (2014)

Reversible assembly of enantiomeric helical polymers: from fibers to gels
por: Leiras, Seila, et al.
Publicado: (2015)

Enantiomeric helical TiO(2) nanofibers modulate different peptide assemblies and subsequent cellular behaviors
por: Jie, Xu, et al.
Publicado: (2019)

Helical springs as a color indicator for determining chirality and enantiomeric excess
por: Maeda, Katsuhiro, et al.
Publicado: (2021)

Macrochirality of Self-Assembled and Co-assembled Supramolecular Structures of a Pair of Enantiomeric Peptides
por: Guo, Zhen, et al.
Publicado: (2021)

Enantiomeric Excesses of Aminonitrile Precursors Determine the Homochirality of Amino Acids
por: Shoji, Mitsuo, et al.
Publicado: (2023)

Enantiomeric Separation and Determination of the Enantiomeric Impurity of Armodafinil by Capillary Electrophoresis with Sulfobutyl Ether-β-cyclodextrin as Chiral Selector
por: Wang, Wei, et al.
Publicado: (2011)

Scalable synthesis and coupling of quaternary α-arylated amino acids: α-aryl substituents are tolerated in α-helical peptides
por: Leonard, Daniel J., et al.
Publicado: (2021)

Role of Helicity on the Anticancer Mechanism of Action of Cationic-Helical Peptides
por: Huang, Yi-Bing, et al.
Publicado: (2012)

Pseudo-enantiomeric chiral components and formation of the helical micro- and nanostructures in charge-transfer complexes
por: Langer, Jerzy J., et al.
Publicado: (2018)

Insights into Abiotically-Generated Amino Acid Enantiomeric Excesses Found in Meteorites
por: Burton, Aaron S., et al.
Publicado: (2018)

Synthesis and Antioxidant Evaluation of Enantiomerically Pure Bis-(1,2,3-triazolylmethyl)amino Esters from Modified α-Amino Acids
por: Sarmiento-Sánchez, Juan I., et al.
Publicado: (2014)

Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides
por: Grelich-Mucha, Manuela, et al.
Publicado: (2021)

Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules
por: Yang, Yang, et al.
Publicado: (2018)

Assembly of mesoscale helices with near-unity enantiomeric excess and light-matter interactions for chiral semiconductors
por: Feng, Wenchun, et al.
Publicado: (2017)

Treatment of Oral Biofilms by a D-Enantiomeric Peptide
por: Zhang, Tian, et al.
Publicado: (2016)

Towards Enantiomerically Pure Unnatural α-Amino Acids via Photoredox Catalytic 1,4-Additions to a Chiral Dehydroalanine
por: Oroz, Paula, et al.
Publicado: (2022)

Removal of Enantiomeric Ibuprofen in a Nanofiltration Membrane Process
por: Higgins, Carlyn J., et al.
Publicado: (2020)

One-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters
por: Silveira-Dorta, Gastón, et al.
Publicado: (2016)

Association energetics of membrane spanning α-helices
por: MacKenzie, Kevin R, et al.
Publicado: (2008)

One-pot analysis of enantiomeric excess of free amino acids by electrospray ionization mass spectrometry
por: Nakakoji, Takashi, et al.
Publicado: (2021)

An electronic circular dichroism spectroscopy method for the quantification of L- and D-amino acids in enantiomeric mixtures
por: Ding, Ruiwen, et al.
Publicado: (2021)

L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment
por: Liang, Chu-Ting, et al.
Publicado: (2016)

Synthesis of Enantiomerically Enriched Protected 2-Amino-, 2,3-Diamino- and 2-Amino-3-Hydroxypropylphosphonates
por: Trocha, Aleksandra, et al.
Publicado: (2023)

Synthesis, characterization and evaluation of antidengue activity of enantiomeric Schiff bases derived from S-substituted dithiocarbazate
por: MARYAM, Maqsood, et al.
Publicado: (2020)

A survey of integral α-helical membrane proteins
por: Kelly, Libusha, et al.
Publicado: (2009)

Single Amino Acid Modifications for Controlling the Helicity of Peptide-Based Chiral Gold Nanoparticle Superstructures
por: Brooks, Sydney C., et al.
Publicado: (2023)

The effects of thioamide backbone substitution on protein stability: a study in α-helical, β-sheet, and polyproline II helical contexts
por: Walters, Christopher R., et al.
Publicado: (2017)

A Racemic Naphthyl‐Coumarin‐Based Probe for Quantitative Enantiomeric Excess Analysis of Amino Acids and Enantioselective Sensing of Amines and Amino Alcohols
por: Li, Jia‐Yi, et al.
Publicado: (2022)

Rational design and application of responsive α-helical peptide hydrogels
por: Banwell, Eleanor F., et al.
Publicado: (2009)

Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering
por: Mehrban, Nazia, et al.
Publicado: (2015)

Assessing Cellular Response to Functionalized α-Helical Peptide Hydrogels
por: Mehrban, Nazia, et al.
Publicado: (2014)

Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity
por: Zhang, Qingzhou, et al.
Publicado: (2016)

Metallohelices emulate the properties of short cationic α-helical peptides
por: Song, Hualong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r5h9d67e08so0q21jumvr625l9