Visfatin Promotes IL-6 and TNF-α Production in Human Synovial Fibroblasts by Repressing miR-199a-5p through ERK, p38 and JNK Signaling Pathways

Osteoarthritis (OA), an inflammatory form of arthritis, is characterized by synovial inflammation and cartilage destruction largely influenced by two key proinflammatory cytokines—interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α). Notably, levels of visfatin (a proinflammatory adipokine) are...

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Detalles Bibliográficos
Autores principales: Wu, Min-Huan, Tsai, Chun-Hao, Huang, Yuan-Li, Fong, Yi-Chin, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796139/
https://www.ncbi.nlm.nih.gov/pubmed/29316707
http://dx.doi.org/10.3390/ijms19010190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796139/
https://www.ncbi.nlm.nih.gov/pubmed/29316707
http://dx.doi.org/10.3390/ijms19010190

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