Cargando…

Introduction of Exogenous HSV-TK Suicide Gene Increases Safety of Keratinocyte-Derived Induced Pluripotent Stem Cells by Providing Genetic “Emergency Exit” Switch

Since their invention in 2006, induced Pluripotent Stem (iPS) cells remain a great promise for regenerative medicine circumventing the ethical issues linked to Embryonic Stem (ES) cell research. iPS cells can be generated in a patient-specific manner as an unlimited source of various cell types for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sułkowski, Maciej, Konieczny, Paweł, Chlebanowska, Paula, Majka, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796146/ https://www.ncbi.nlm.nih.gov/pubmed/29315221 http://dx.doi.org/10.3390/ijms19010197

Ejemplares similares

Origin of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons
por: Chlebanowska, Paula, et al.
Publicado: (2020)

Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson’s Disease
por: Chlebanowska, Paula, et al.
Publicado: (2020)

Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases
por: Oishi, Tomoya, et al.
Publicado: (2022)

Impact of AMPK on cervical carcinoma progression and metastasis
por: Konieczny, Paweł, et al.
Publicado: (2023)

Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication
por: Xiao, Jianyong, et al.
Publicado: (2016)

Molecular and Functional Verification of Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) Pluripotency
por: Musiał-Wysocka, Aleksandra, et al.
Publicado: (2019)

An experimental study on cervix cancer with combination of HSV-TK/GCV suicide gene therapy system and (60)Co radiotherapy
por: Chen, Daozhen, et al.
Publicado: (2010)

Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene
por: Chendeb, Mariam, et al.
Publicado: (2017)

Hypoxia-directed tumor targeting of CRISPR-Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles
por: Davis, Alicia, et al.
Publicado: (2022)

Using HSV-TK/GCV suicide gene therapy to inhibit lens epithelial cell proliferation for treatment of posterior capsular opacification
por: Jiang, Yong-Xiang, et al.
Publicado: (2011)

Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
por: Li, Lei-qing, et al.
Publicado: (2013)

Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells
por: Robe, Pierre A, et al.
Publicado: (2005)

Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir
por: Ladd, Brendon, et al.
Publicado: (2011)

Synergistic effect of resveratrol and HSV-TK/GCV therapy on murine hepatoma cells
por: Xiao, Jianyong, et al.
Publicado: (2018)

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma
por: Dührsen, Lasse, et al.
Publicado: (2019)

Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
por: Cho, Hyun-Sang, et al.
Publicado: (2004)

HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer
por: Lifang, Yang, et al.
Publicado: (2008)

Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene
por: Hung, Chien-Fu, et al.
Publicado: (2012)

HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model
por: Kenarkoohi, Azra, et al.
Publicado: (2020)

Improving the safety of cell therapy with the TK-suicide gene
por: Greco, Raffaella, et al.
Publicado: (2015)

CBMS-08 INVESTIGATION FOR NICOTINIC EFFECTS ON STEM CELL’S PROPERTY IN HSV-TK/GCV GENE THERAPY
por: Kenmochi, Hiroaki, et al.
Publicado: (2019)

Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy
por: Sawdon, Alicia J., et al.
Publicado: (2021)

Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics
por: Rousseau, Antoine, et al.
Publicado: (2022)

Taking the RISC of exiting naïve pluripotency
por: Guallar, Diana, et al.
Publicado: (2016)

The Roles of Macrophages and Nitric Oxide in Interleukin-3-Enhanced HSV-Sr39tk-Mediated Prodrug Therapy
por: Yu, Ching-Fang, et al.
Publicado: (2013)

HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK
por: Yi, Quan-Yong, et al.
Publicado: (2018)

Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer
por: Yanagisawa, Nobuyuki, et al.
Publicado: (2021)

Carbon Fibers as a New Type of Scaffold for Midbrain Organoid Development
por: Tejchman, Anna, et al.
Publicado: (2020)

Concise Review: Mesenchymal Stem Cells in Cardiovascular Regeneration: Emerging Research Directions and Clinical Applications
por: Majka, Marcin, et al.
Publicado: (2017)

Mesenchymal stem cells as a multimodal treatment for nervous system diseases
por: Badyra, Bogna, et al.
Publicado: (2020)

Pluripotency retention and exogenous mRNA introduction in planarian stem cells in culture
por: Lei, Kai, et al.
Publicado: (2023)

Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction
por: Suryawanshi, Rahul K., et al.
Publicado: (2023)

Highly Effective Protocol for Differentiation of Induced Pluripotent Stem Cells (iPS) into Melanin-Producing Cells
por: Sułkowski, Maciej, et al.
Publicado: (2021)

De Novo Synthesis of VP16 Coordinates the Exit from HSV Latency In Vivo
por: Thompson, Richard L., et al.
Publicado: (2009)

Long term follow up of patients after allogeneic stem cell transplantation and transfusion of HSV-TK transduced T-cells
por: Weissinger, Eva M., et al.
Publicado: (2015)

The Possible Mechanisms of HSV-TK/Hyperthermia Combined with 131I-antiAFPMcAb-GCV Nanospheres to Treat Hepatoma
por: Lin, Mei, et al.
Publicado: (2018)

Brd4‐Brd2 isoform switching coordinates pluripotent exit and Smad2‐dependent lineage specification
por: Fernandez‐Alonso, Rosalia, et al.
Publicado: (2017)

Regenerative Potential of the Product “CardioCell” Derived from the Wharton’s Jelly Mesenchymal Stem Cells for Treating Hindlimb Ischemia
por: Musiał-Wysocka, Aleksandra, et al.
Publicado: (2019)

Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis
por: Tyszka-Czochara, Malgorzata, et al.
Publicado: (2017)

The Anti-Tumor Effects of Adipose Tissue Mesenchymal Stem Cell Transduced with HSV-Tk Gene on U-87-Driven Brain Tumor
por: de Melo, Suely Maymone, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_442o765u6qvvqgahog6irveq9e