Cargando…

Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors

The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-tri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nastasă, Cristina, Vodnar, Dan C., Ionuţ, Ioana, Stana, Anca, Benedec, Daniela, Tamaian, Radu, Oniga, Ovidiu, Tiperciuc, Brînduşa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796171/ https://www.ncbi.nlm.nih.gov/pubmed/29324679 http://dx.doi.org/10.3390/ijms19010222

Ejemplares similares

New Thiazolyl-triazole Schiff Bases: Synthesis and Evaluation of the Anti-Candida Potential
por: Stana, Anca, et al.
Publicado: (2016)

Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles
por: Tamaian, Radu, et al.
Publicado: (2015)

Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors
por: Stana, Anca, et al.
Publicado: (2019)

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells
por: Login, Cristian Cezar, et al.
Publicado: (2019)

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors
por: Stana, Anca, et al.
Publicado: (2017)

5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma
por: Nastasă, Cristina, et al.
Publicado: (2019)

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation
por: Nastasă, Cristina, et al.
Publicado: (2015)

Synthesis of New Phenolic Derivatives of Quinazolin-4(3H)-One as Potential Antioxidant Agents—In Vitro Evaluation and Quantum Studies
por: Pele, Raluca, et al.
Publicado: (2022)

Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines
por: STOICA, CRISTINA IOANA, et al.
Publicado: (2015)

A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies
por: Borcea, Anca-Maria, et al.
Publicado: (2019)

Development of new 5-(chromene-3-yl)methylene-2,4-thiazolidinediones as antimicrobial agents
por: NASTASĂ, CRISTINA MARIANA, et al.
Publicado: (2016)

Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular Docking Study, and Spectroscopic Investigation of their Binding Interaction with Bovine Serum Albumin
por: Pricopie, Andreea-Iulia, et al.
Publicado: (2019)

Achillea schurii Flowers: Chemical, Antioxidant, and Antimicrobial Investigations
por: Benedec, Daniela, et al.
Publicado: (2016)

Sources for developing new medicinal products: biochemical investigations on alcoholic extracts obtained from aerial parts of some Romanian Amaryllidaceae species
por: Benedec, Daniela, et al.
Publicado: (2018)

Agastache Species: A Comprehensive Review on Phytochemical Composition and Therapeutic Properties
por: Nechita, Mihaela-Ancuța, et al.
Publicado: (2023)

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
por: Borcea, Anca-Maria, et al.
Publicado: (2021)

Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential
por: Benedec, Daniela, et al.
Publicado: (2023)

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation
por: Pele, Raluca, et al.
Publicado: (2022)

Synthesis of Schiff Bases and Isoindolyl- and Thiazolyl-Substituted Quinolines from 6-Amino-2-methylquinolin-4-ol
por: Aleqsanyan, I. L., et al.
Publicado: (2022)

New Phenolic Derivatives of Thiazolidine-2,4-dione with Antioxidant and Antiradical Properties: Synthesis, Characterization, In Vitro Evaluation, and Quantum Studies
por: Marc, Gabriel, et al.
Publicado: (2019)

Polyphenolic Composition, Antioxidant and Antibacterial Activities for Two Romanian Subspecies of Achillea distans Waldst. et Kit. ex Willd
por: Benedec, Daniela, et al.
Publicado: (2013)

Structure–Activity Relationship Studies Based on Quinazoline Derivatives as EGFR Kinase Inhibitors (2017–Present)
por: Șandor, Alexandru, et al.
Publicado: (2023)

The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation
por: Araniciu, Cătălin, et al.
Publicado: (2014)

Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1,2,4-triazole Schiff base
por: Chen, Ying, et al.
Publicado: (2019)

New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
por: Epure, Alexandra, et al.
Publicado: (2023)

Schiff Bases of Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase (†)
por: Aboul-Fadl, Tarek, et al.
Publicado: (2011)

Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening
por: Marc, Gabriel, et al.
Publicado: (2021)

Synthesis and Antibacterial Evaluation of New Thione Substituted 1,2,4-Triazole Schiff Bases as Novel Antimicrobial Agents
por: Akbari Dilmaghani, Karim, et al.
Publicado: (2015)

Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Candida Activity Evaluation and Interaction with Bovine Serum Albumine
por: Pricopie, Andreea-Iulia, et al.
Publicado: (2020)

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase
por: Walker, Scott S., et al.
Publicado: (2017)

Synthesis of Triazole Schiff’s Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity
por: Yu, Feng, et al.
Publicado: (2015)

Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues
por: Carbone, Anna, et al.
Publicado: (2015)

Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives
por: Osman, Hasnah, et al.
Publicado: (2012)

An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation
por: Elsharabasy, Fatma S., et al.
Publicado: (2017)

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
por: Sultan, Aeysha, et al.
Publicado: (2020)

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
por: Chan, Pan F., et al.
Publicado: (2015)

Synthesis of Novel Bisindolylmethane Schiff bases and Their Antibacterial Activity
por: Imran, Syahrul, et al.
Publicado: (2014)

Antibacterial coating on biocomposites for cranio-facial reconstruction
por: LAZAR, MADALINA ANCA, et al.
Publicado: (2016)

Retraction: A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
Publicado: (2020)

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation
por: Marc, Gabriel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m0e3jl06kcaa9v4rrb05dob1c5