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Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome

Telomeres are transcribed into noncoding telomeric repeat-containing RNAs (TERRA), which are essential for telomere maintenance. Deregulation of TERRA transcription impairs telomere metabolism and a role in tumorigenesis has been proposed. Head and neck cancer (HNC) is one of the most frequent cance...

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Autores principales: Vitelli, Valerio, Falvo, Paolo, G. Nergadze, Solomon, Santagostino, Marco, Khoriauli, Lela, Pellanda, Paola, Bertino, Giulia, Occhini, Antonio, Benazzo, Marco, Morbini, Patrizia, Paulli, Marco, Porta, Camillo, Giulotto, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796220/
https://www.ncbi.nlm.nih.gov/pubmed/29342094
http://dx.doi.org/10.3390/ijms19010274
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author Vitelli, Valerio
Falvo, Paolo
G. Nergadze, Solomon
Santagostino, Marco
Khoriauli, Lela
Pellanda, Paola
Bertino, Giulia
Occhini, Antonio
Benazzo, Marco
Morbini, Patrizia
Paulli, Marco
Porta, Camillo
Giulotto, Elena
author_facet Vitelli, Valerio
Falvo, Paolo
G. Nergadze, Solomon
Santagostino, Marco
Khoriauli, Lela
Pellanda, Paola
Bertino, Giulia
Occhini, Antonio
Benazzo, Marco
Morbini, Patrizia
Paulli, Marco
Porta, Camillo
Giulotto, Elena
author_sort Vitelli, Valerio
collection PubMed
description Telomeres are transcribed into noncoding telomeric repeat-containing RNAs (TERRA), which are essential for telomere maintenance. Deregulation of TERRA transcription impairs telomere metabolism and a role in tumorigenesis has been proposed. Head and neck cancer (HNC) is one of the most frequent cancers worldwide, with head and neck squamous cell carcinoma (HNSCC) being the predominant type. Since HNSCC patients are characterized by altered telomere maintenance, a dysfunction in telomere transcription can be hypothesized. In this prospective study, we compared TERRA levels in the tumor and matched normal tissue from 23 HNSCC patients. We then classified patients in two categories according to the level of TERRA expression in the tumor compared to the normal tissue: (1) lower expression in the tumor, (2) higher or similar expression in tumor. A significant proportion of patients in the first group died of the disease within less than 34 months postsurgery, while the majority of patients in the second group were alive and disease-free. Our results highlight a striking correlation between TERRA expression and tumor aggressiveness in HNSCC suggesting that TERRA levels may be proposed as a novel molecular prognostic marker for HNSCC.
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spelling pubmed-57962202018-02-09 Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome Vitelli, Valerio Falvo, Paolo G. Nergadze, Solomon Santagostino, Marco Khoriauli, Lela Pellanda, Paola Bertino, Giulia Occhini, Antonio Benazzo, Marco Morbini, Patrizia Paulli, Marco Porta, Camillo Giulotto, Elena Int J Mol Sci Article Telomeres are transcribed into noncoding telomeric repeat-containing RNAs (TERRA), which are essential for telomere maintenance. Deregulation of TERRA transcription impairs telomere metabolism and a role in tumorigenesis has been proposed. Head and neck cancer (HNC) is one of the most frequent cancers worldwide, with head and neck squamous cell carcinoma (HNSCC) being the predominant type. Since HNSCC patients are characterized by altered telomere maintenance, a dysfunction in telomere transcription can be hypothesized. In this prospective study, we compared TERRA levels in the tumor and matched normal tissue from 23 HNSCC patients. We then classified patients in two categories according to the level of TERRA expression in the tumor compared to the normal tissue: (1) lower expression in the tumor, (2) higher or similar expression in tumor. A significant proportion of patients in the first group died of the disease within less than 34 months postsurgery, while the majority of patients in the second group were alive and disease-free. Our results highlight a striking correlation between TERRA expression and tumor aggressiveness in HNSCC suggesting that TERRA levels may be proposed as a novel molecular prognostic marker for HNSCC. MDPI 2018-01-17 /pmc/articles/PMC5796220/ /pubmed/29342094 http://dx.doi.org/10.3390/ijms19010274 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vitelli, Valerio
Falvo, Paolo
G. Nergadze, Solomon
Santagostino, Marco
Khoriauli, Lela
Pellanda, Paola
Bertino, Giulia
Occhini, Antonio
Benazzo, Marco
Morbini, Patrizia
Paulli, Marco
Porta, Camillo
Giulotto, Elena
Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title_full Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title_fullStr Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title_full_unstemmed Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title_short Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
title_sort telomeric repeat-containing rnas (terra) decrease in squamous cell carcinoma of the head and neck is associated with worsened clinical outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796220/
https://www.ncbi.nlm.nih.gov/pubmed/29342094
http://dx.doi.org/10.3390/ijms19010274
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