Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

Cardiovascular disease is the leading cause of morbidity/mortality worldwide. Metformin is the first therapy offering cardioprotection in type 2 diabetes and non-diabetic animals with unknown mechanism. We have shown that metformin improves angiogenesis via affecting expression of growth factors/ang...

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Detalles Bibliográficos
Autores principales: Bakhashab, Sherin, Ahmed, Farid, Schulten, Hans-Juergen, Ahmed, Fahad W., Glanville, Michael, Al-Qahtani, Mohammed H., Weaver, Jolanta U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796238/
https://www.ncbi.nlm.nih.gov/pubmed/29351188
http://dx.doi.org/10.3390/ijms19010293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796238/
https://www.ncbi.nlm.nih.gov/pubmed/29351188
http://dx.doi.org/10.3390/ijms19010293

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