Identification of a Rare Germline Heterozygous Deletion Involving the Polycistronic miR-17–92 Cluster in Two First-Degree Relatives from a BRCA 1/2 Negative Chilean Family with Familial Breast Cancer: Possible Functional Implications

Micro-RNAs (miRNAs) have emerged as novel gene expression regulators. Recent evidence strongly suggests a role for miRNAs in a large variety of cancer-related pathways. Different studies have shown that 18.7 to 37% of all human miRNA genes are clustered. miR-17–92 polycistronic cluster overexpressio...

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Detalles Bibliográficos
Autores principales: de Mayo, Tomás, Ziegler, Annemarie, Morales, Sebastián, Jara, Lilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796264/
https://www.ncbi.nlm.nih.gov/pubmed/29361751
http://dx.doi.org/10.3390/ijms19010321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796264/
https://www.ncbi.nlm.nih.gov/pubmed/29361751
http://dx.doi.org/10.3390/ijms19010321

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