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Rebound excitability mediates motor abnormalities in Parkinson’s disease

Parkinson’s disease (PD) is a debilitating disorder resulting from loss of dopamine neurons. In dopamine deficient state, the basal ganglia increases inhibitory synaptic outputs to the thalamus. This increased inhibition by the basal ganglia output is known to reduce firing rate of thalamic neurons...

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Detalles Bibliográficos
Autores principales: Kim, Jeongjin, Kim, Daesoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796627/
https://www.ncbi.nlm.nih.gov/pubmed/29335072
http://dx.doi.org/10.5483/BMBRep.2018.51.1.004