Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation

Non-small-cell lung cancer (NSCLC) is commonly caused by a mutation in the epidermal growth factor receptor (EGFR) and subsequent aberrant EGFR signaling with uncontrolled kinase activity. A deletion mutation in EGFR exon 19 is frequently observed in EGFR gene mutations. We designed a DNAzyme to sup...

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Detalles Bibliográficos
Autores principales: Jang, Dahye, Baek, Yu Mi, Park, Hanna, Hwang, Yeo Eun, Kim, Dong-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796631/
https://www.ncbi.nlm.nih.gov/pubmed/28893372
http://dx.doi.org/10.5483/BMBRep.2018.51.1.163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796631/
https://www.ncbi.nlm.nih.gov/pubmed/28893372
http://dx.doi.org/10.5483/BMBRep.2018.51.1.163

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