Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2

Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for cancer therapy. We report that unlike its structura...

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Detalles Bibliográficos
Autores principales: Shankar Babu, Mani, Mahanta, Sailendra, Lakhter, Alexander J., Hato, Takashi, Paul, Subhankar, Naidu, Samisubbu R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796696/
https://www.ncbi.nlm.nih.gov/pubmed/29394289
http://dx.doi.org/10.1371/journal.pone.0191419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796696/
https://www.ncbi.nlm.nih.gov/pubmed/29394289
http://dx.doi.org/10.1371/journal.pone.0191419

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