Cargando…

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2

Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for cancer therapy. We report that unlike its structura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shankar Babu, Mani, Mahanta, Sailendra, Lakhter, Alexander J., Hato, Takashi, Paul, Subhankar, Naidu, Samisubbu R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796696/ https://www.ncbi.nlm.nih.gov/pubmed/29394289 http://dx.doi.org/10.1371/journal.pone.0191419

Ejemplares similares

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma
por: Lakhter, Alexander J., et al.
Publicado: (2014)

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
por: Zhao, Xiaoyue, et al.
Publicado: (2018)

Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 domain Mediated PUMA Degradation
por: Lakhter, Alexander J, et al.
Publicado: (2013)

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation
por: Liu, Yun-zi, et al.
Publicado: (2021)

Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
por: Rajala, Raju V. S.
Publicado: (2020)

Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells
por: Li, Liangwei, et al.
Publicado: (2020)

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2
por: van de Wetering, Cheryl, et al.
Publicado: (2021)

Pantothenate Kinase 4 Governs Lens Epithelial Fibrosis by Negatively Regulating Pyruvate Kinase M2-Related Glycolysis
por: Li, Xue, et al.
Publicado: (2023)

MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells
por: Kosugi, Michio, et al.
Publicado: (2011)

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
por: Liu, Jia, et al.
Publicado: (2014)

HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells
por: Huang, Liangqian, et al.
Publicado: (2014)

Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster
por: Costa, Wender Ferreira, et al.
Publicado: (2010)

In vitro effects of lapachol and β-lapachone against Leishmania amazonensis
por: Ramos-Milaré, Á.C.F.H., et al.
Publicado: (2023)

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
por: Peres, Raphael S., et al.
Publicado: (2017)

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
por: Coassolo, Sébastien, et al.
Publicado: (2021)

Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling
por: Kim, Eunhwan, et al.
Publicado: (2023)

Andrographolide suppresses aerobic glycolysis and induces apoptotic cell death by inhibiting pyruvate dehydrogenase kinase 1 expression
por: Yang, Eun-Sun, et al.
Publicado: (2023)

Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
por: Dai, Yitian, et al.
Publicado: (2022)

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms
por: Strauch, Marcelo A., et al.
Publicado: (2019)

Development of long-circulating lapachol nanoparticles: formation, characterization, pharmacokinetics, distribution and cytotoxicity
por: Chen, Qunying, et al.
Publicado: (2020)

Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model
por: Mendes Miranda, Sued Eustáquio, et al.
Publicado: (2021)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer
por: Li, Linlin, et al.
Publicado: (2017)

Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
por: Almouhanna, Fadi, et al.
Publicado: (2021)

NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase
por: Gu, Zhimin, et al.
Publicado: (2017)

Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
por: Horemans, Steff, et al.
Publicado: (2022)

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
por: Flora, Gagan D., et al.
Publicado: (2023)

MiR‐5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
por: Miao, Yongchang, et al.
Publicado: (2020)

ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE
por: MATA-SANTOS, Taís, et al.
Publicado: (2015)

Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity
por: de Oliveira, Ludmila G., et al.
Publicado: (2011)

Pyruvate Kinase Deficiency Causing Priapism
por: Shankar, Vinay Hanyalu, et al.
Publicado: (2023)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

In Silico Screening, Genotyping, Molecular Dynamics Simulation and Activity Studies of SNPs in Pyruvate Kinase M2
por: Kalaiarasan, Ponnusamy, et al.
Publicado: (2015)

Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
por: Rocha, Marcele Neves, et al.
Publicado: (2013)

Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial–Mesenchymal Transition
por: Zou, Jun, et al.
Publicado: (2021)

Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death
por: Kang, Beom-Seok, et al.
Publicado: (2023)

Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa
por: Hereng, T.H., et al.
Publicado: (2011)

Ethyl Pyruvate Promotes Proliferation of Regulatory T Cells by Increasing Glycolysis
por: Koprivica, Ivan, et al.
Publicado: (2020)

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis
por: Guo, Jianshuang, et al.
Publicado: (2019)

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
por: Jia, Guizhi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q2b4iu78r2n768jjbk52unndp9