Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells transformed with KRAS(G12V), and driven by MAP...

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Detalles Bibliográficos
Autores principales: Martinko, Alexander J, Truillet, Charles, Julien, Olivier, Diaz, Juan E, Horlbeck, Max A, Whiteley, Gordon, Blonder, Josip, Weissman, Jonathan S, Bandyopadhyay, Sourav, Evans, Michael J, Wells, James A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796798/
https://www.ncbi.nlm.nih.gov/pubmed/29359686
http://dx.doi.org/10.7554/eLife.31098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796798/
https://www.ncbi.nlm.nih.gov/pubmed/29359686
http://dx.doi.org/10.7554/eLife.31098

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