Cargando…

Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways

CREB (cAMP Response Element Binding protein) is a transcription factor that is overexpressed in primary acute myeloid leukemia (AML) cells and associated with a decreased event-free survival and increased risk of relapse. We recently reported a small molecule inhibitor of CREB, XX-650-23, which inhi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chae, Hee-Don, Cox, Nick, Dahl, Gary V., Lacayo, Norman J., Davis, Kara L., Capolicchio, Samanta, Smith, Mark, Sakamoto, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796975/ https://www.ncbi.nlm.nih.gov/pubmed/29435104 http://dx.doi.org/10.18632/oncotarget.23794

Ejemplares similares

Replication factor C3 is a CREB Target Gene that Regulates Cell Cycle Progression through Modulation of Chromatin Loading of PCNA
por: Chae, Hee-Don, et al.
Publicado: (2014)

Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?
por: Wojcicki, Anna V., et al.
Publicado: (2020)

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit
por: Chae, Hee-Don, et al.
Publicado: (2020)

Expression profile of CREB knockdown in myeloid leukemia cells
por: Pellegrini, Matteo, et al.
Publicado: (2008)

Small Molecule Inhibition of cAMP Response Element Binding Protein in Human Acute Myeloid Leukemia Cells
por: Mitton, Bryan, et al.
Publicado: (2016)

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia
por: Jacamo, Rodrigo, et al.
Publicado: (2017)

An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells
por: Zaidi, Sayyed K., et al.
Publicado: (2017)

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34(+) proliferating and quiescent chronic myeloid leukemia blast crisis cells
por: Carter, Bing Z., et al.
Publicado: (2015)

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia
por: Tagde, Ashujit, et al.
Publicado: (2016)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ
por: Bolsoni-Lopes, Andressa, et al.
Publicado: (2015)

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells
por: Clavijo, Paul E., et al.
Publicado: (2017)

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
por: Bryant, Kelly G., et al.
Publicado: (2017)

Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters
por: Mitton, Bryan, et al.
Publicado: (2016)

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia
por: Hamdoun, Sami, et al.
Publicado: (2017)

Niclosamide suppresses Hepatoma cell proliferation via the Wnt pathway
por: Tomizawa, Minoru, et al.
Publicado: (2013)

MEK1 is required for the development of NRAS-driven leukemia
por: Nowacka, Joanna D., et al.
Publicado: (2016)

PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
por: Zhou, Mi, et al.
Publicado: (2022)

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia
por: McArthur, Kate, et al.
Publicado: (2017)

Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia
por: Yadav, Babasaheb D., et al.
Publicado: (2016)

Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy
por: Sandri, Sara, et al.
Publicado: (2017)

Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias
por: Sattari, Arash, et al.
Publicado: (2016)

The magic bullet: Niclosamide
por: Jiang, Haowen, et al.
Publicado: (2022)

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation
por: Lin, Shan, et al.
Publicado: (2016)

Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia
por: Mukherjee, Kaushiki, et al.
Publicado: (2017)

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation
por: Mardilovich, Katerina, et al.
Publicado: (2015)

Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia
por: Cerny-Reiterer, Sabine, et al.
Publicado: (2014)

BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia
por: Li, Yulin, et al.
Publicado: (2016)

The downregulation of putative anticancer target BORIS/CTCFL in an addicted myeloid cancer cell line modulates the expression of multiple protein coding and ncRNA genes
por: Teplyakov, Evgeny, et al.
Publicado: (2017)

Cell immortalization facilitates prelamin A clearance by increasing both cell proliferation and autophagic flux
por: González-Blanco, Carlos, et al.
Publicado: (2022)

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells
por: Zhang, Chuanzhao, et al.
Publicado: (2016)

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model
por: Hasan, Md. Nabiul, et al.
Publicado: (2014)

Transcriptional regulation of HSPB1 by Friend leukemia integration-1 factor modulates radiation and temozolomide resistance in glioblastoma
por: Rajesh, Yetirajam, et al.
Publicado: (2020)

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
por: Kim, Taewan, et al.
Publicado: (2015)

A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia
por: Kay, Neil E., et al.
Publicado: (2016)

Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells
por: Liu, Han, et al.
Publicado: (2017)

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts
por: Valletta, Simona, et al.
Publicado: (2015)

Loss of Egr1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia
por: Maifrede, Silvia, et al.
Publicado: (2017)

Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3
por: Nagai, Kozo, et al.
Publicado: (2018)

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study
por: Karlsson, Questa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i6c6amc3vglib6iuiluiju9a64