A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma

Sonic Hedgehog (Shh) pathway regulates embryonic development of different organs including the thyroid gland. The aberrant activation of Shh signaling has been found in several types of cancer and according to recent evidences it represents an important regulator of tumor-stroma interaction. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Parascandolo, Alessia, Laukkanen, Mikko O., De Rosa, Nancy, Ugolini, Clara, Cantisani, Maria Carmela, Cirafici, Anna Maria, Basolo, Fulvio, Santoro, Massimo, Castellone, Maria Domenica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796990/
https://www.ncbi.nlm.nih.gov/pubmed/29435119
http://dx.doi.org/10.18632/oncotarget.23388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796990/
https://www.ncbi.nlm.nih.gov/pubmed/29435119
http://dx.doi.org/10.18632/oncotarget.23388

Ejemplares similares