Cis-trimethoxy resveratrol induces intrinsic apoptosis via prometaphase arrest and prolonged CDK1 activation pathway in human Jurkat T cells

Cis-trimethoxy resveratrol (cis-3M-RES) induced dose-dependent cytotoxicity and apoptotic DNA fragmentation in Jurkat T cell clones (JT/Neo); however, it induced only cytostasis in BCL-2-overexpressing cells (JT/BCL-2). Treatment with 0.25 μM cis-3M-RES induced G(2)/M arrest, BAK activation, Δψm los...

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Detalles Bibliográficos
Autores principales: Kim, Chae Eun, Jun, Do Youn, Kim, Jong-Sik, Kim, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797027/
https://www.ncbi.nlm.nih.gov/pubmed/29435156
http://dx.doi.org/10.18632/oncotarget.23576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797027/
https://www.ncbi.nlm.nih.gov/pubmed/29435156
http://dx.doi.org/10.18632/oncotarget.23576

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