DNA damage in leukocytes after internal ex-vivo irradiation of blood with the α-emitter Ra-223

Irradiation with high linear energy transfer α-emitters, like the clinically used Ra-223 dichloride, severely damages cells and induces complex DNA damage including closely spaced double-strand breaks (DSBs). As the hematopoietic system is an organ-at-risk for the treatment, knowledge about Ra-223-i...

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Detalles Bibliográficos
Autores principales: Schumann, Sarah, Eberlein, Uta, Muhtadi, Razan, Lassmann, Michael, Scherthan, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797089/
https://www.ncbi.nlm.nih.gov/pubmed/29396412
http://dx.doi.org/10.1038/s41598-018-20364-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797089/
https://www.ncbi.nlm.nih.gov/pubmed/29396412
http://dx.doi.org/10.1038/s41598-018-20364-7

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