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DNA damage in leukocytes after internal ex-vivo irradiation of blood with the α-emitter Ra-223
Irradiation with high linear energy transfer α-emitters, like the clinically used Ra-223 dichloride, severely damages cells and induces complex DNA damage including closely spaced double-strand breaks (DSBs). As the hematopoietic system is an organ-at-risk for the treatment, knowledge about Ra-223-i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797089/ https://www.ncbi.nlm.nih.gov/pubmed/29396412 http://dx.doi.org/10.1038/s41598-018-20364-7 |