Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro

Age-related macular degeneration (AMD) is characterized by pathological changes in the retinal pigment epithelium (RPE) and loss of photoreceptors. Growing evidence has demonstrated that reactive microglial cells trigger RPE dysfunction and loss of photoreceptors, and inflammasome pathways and compl...

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Detalles Bibliográficos
Autores principales: Madeira, M. H., Rashid, K., Ambrósio, A. F., Santiago, A. R., Langmann, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797099/
https://www.ncbi.nlm.nih.gov/pubmed/29396515
http://dx.doi.org/10.1038/s41598-018-20733-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797099/
https://www.ncbi.nlm.nih.gov/pubmed/29396515
http://dx.doi.org/10.1038/s41598-018-20733-2

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