Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions

Cancer-specific promoter driven replication of oncolytic adenovirus (Ad) is cancer-specific, but shows low transcriptional activity. Thus, we generated several chimeric α-fetoprotein (AFP) promoter variants, containing reconstituted enhancer and silencer regions, to preferentially drive Ad replicati...

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Detalles Bibliográficos
Autores principales: Yoon, A-Rum, Hong, JinWoo, Kim, Minjung, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797125/
https://www.ncbi.nlm.nih.gov/pubmed/29396500
http://dx.doi.org/10.1038/s41598-018-20268-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797125/
https://www.ncbi.nlm.nih.gov/pubmed/29396500
http://dx.doi.org/10.1038/s41598-018-20268-6

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