Cargando…

Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening

Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The influenza polymerase with three proteins, PA, PB1 and PB2, is a crucial component of the viral ribonucleoprotein (RNP) complex. Her...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lo, Chun-Yeung, Li, Olive Tin-Wai, Tang, Wen-Ping, Hu, Chun, Wang, Guo Xin, Ngo, Jacky Chi-Ki, Wan, David Chi-Cheong, Poon, Leo Lit-Man, Shaw, Pang-Chui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797126/ https://www.ncbi.nlm.nih.gov/pubmed/29396435 http://dx.doi.org/10.1038/s41598-018-20772-9

Ejemplares similares

A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase
por: Xu, Xinzhou, et al.
Publicado: (2021)

Using recombinant adhesive proteins as durable and green flame-retardant coatings
por: Leong, Weng I., et al.
Publicado: (2021)

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
por: Datta, Kausiki, et al.
Publicado: (2013)

Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein
por: Hsia, Ho-Pan, et al.
Publicado: (2018)

Functional Importance of the Hydrophobic Residue 362 in Influenza A PB1 Subunit
por: Chan, Johnson Jor-Shing, et al.
Publicado: (2023)

Recent Advances in Surface Plasmon Resonance Imaging Sensors
por: Wang, Dongping, et al.
Publicado: (2019)

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
por: Jordan, Paul C., et al.
Publicado: (2018)

DNA from herbs can be obtained from air and authenticated by polymerase chain reaction
por: Ngai, Hiu-Lam, et al.
Publicado: (2023)

The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome
por: Binh, Nguyen Trong, et al.
Publicado: (2013)

Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation
por: Li, Olive T. W., et al.
Publicado: (2009)

Increased Stability of SARS-CoV-2 Omicron Variant over Ancestral Strain
por: Chin, Alex Wing Hong, et al.
Publicado: (2022)

HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products
por: Yik, Mavis Hong-Yu, et al.
Publicado: (2021)

Substitution at Aspartic Acid 1128 in the SARS Coronavirus Spike Glycoprotein Mediates Escape from a S2 Domain-Targeting Neutralizing Monoclonal Antibody
por: Ng, Oi-Wing, et al.
Publicado: (2014)

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease
por: Vivien Chiu, Wai Yin, et al.
Publicado: (2017)

Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor
por: Meng, Xin, et al.
Publicado: (2021)

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function
por: Liu, Lu, et al.
Publicado: (2023)

Laser Printing of Superhydrophobic Patterns from Mixtures of Hydrophobic Silica Nanoparticles and Toner Powder
por: Ngo, Chi-Vinh, et al.
Publicado: (2016)

Patent applications for using DNA technologies to authenticate medicinal herbal material
por: Shaw, Pang-Chui, et al.
Publicado: (2009)

A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity
por: Chin, Alex W. H., et al.
Publicado: (2013)

Gouty tophus: Unusual case of nasal lump
por: Shiu, Wai Hung Lester, et al.
Publicado: (2021)

Global sagittal alignment of the spine, pelvis, lower limb after vertebral compression fracture and its effect on quality of life
por: Chau, Leo Tsz Ching, et al.
Publicado: (2021)

The N-Terminal Region of the PA Subunit of the RNA Polymerase of Influenza A/HongKong/156/97 (H5N1) Influences Promoter Binding
por: Kashiwagi, Takahito, et al.
Publicado: (2009)

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein
por: Liu, Ming, et al.
Publicado: (2015)

Disengaging polymerase: Terminating RNA polymerase II transcription in budding yeast()
por: Mischo, Hannah E., et al.
Publicado: (2013)

Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain
por: Pineda, Gabriel, et al.
Publicado: (2015)

High-Throughput Immunological Analysis of Dictamni Cortex: Implication in the Quality Control of Herbal Medicine
por: Tsang, Miranda Sin-Man, et al.
Publicado: (2019)

Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C)
por: Fong, Wai-Ying, et al.
Publicado: (2017)

A spiral plasmonic lens with directional excitation of surface plasmons
por: Guo, Qingrui, et al.
Publicado: (2016)

Emerging roles of the neural adaptor FE65 in neurite outgrowth
por: Li, Wen, et al.
Publicado: (2018)

End-stage knee osteoarthritis with and without sarcopenia and the effect of knee arthroplasty – a prospective cohort study
por: Ho, Kevin Ki-Wai, et al.
Publicado: (2021)

Mutational Analyses of the Influenza A Virus Polymerase Subunit PA Reveal Distinct Functions Related and Unrelated to RNA Polymerase Activity
por: Liang, Yuhong, et al.
Publicado: (2012)

HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit
por: Chen, Huan, et al.
Publicado: (2019)

Vaccine Resistance and Hesitancy among Older Adults Who Live Alone or Only with an Older Partner in Community in the Early Stage of the Fifth Wave of COVID-19 in Hong Kong
por: Zhang, Dexing, et al.
Publicado: (2022)

Controlling the Wetting Properties of Superhydrophobic Titanium Surface Fabricated by UV Nanosecond-Pulsed Laser and Heat Treatment
por: Dinh, The-Hung, et al.
Publicado: (2018)

Development and Validation of the PaP Score Nomogram for Terminally Ill Cancer Patients
por: Scarpi, Emanuela, et al.
Publicado: (2022)

Comparison of DNA extraction methods on CITES-listed timber species and application in species authentication of commercial products using DNA barcoding
por: But, Grace Wing-Chiu, et al.
Publicado: (2023)

Solution Structure and Rpn1 Interaction of the UBL Domain of Human RNA Polymerase II C-Terminal Domain Phosphatase
por: Yun, Ji-Hye, et al.
Publicado: (2013)

PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain
por: Abbas, Ata, et al.
Publicado: (2019)

Oral health status and behaviours of preschool children in Hong Kong
por: Chu, Chun-Hung, et al.
Publicado: (2012)

I-60 Structural study of RNA polymerase PA subunit from an avian influenza virus
por: Liu, Y.F.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_5n7gvdbkjq5qmqe644r52bllmj