Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships

Fatty acid nitroalkene derivatives (NO(2)-FA) activate Nrf2-regulated antioxidant gene expression and inhibit NF-κB-dependent cytokine expression. To better define NO(2)-FA structure-function relationships, a series of 22 new chemical entities (NCEs) containing an electrophilic nitroalkene functiona...

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Detalles Bibliográficos
Autores principales: Khoo, Nicholas K. H., Li, Lihua, Salvatore, Sonia R., Schopfer, Francisco J., Freeman, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797128/
https://www.ncbi.nlm.nih.gov/pubmed/29396403
http://dx.doi.org/10.1038/s41598-018-20460-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797128/
https://www.ncbi.nlm.nih.gov/pubmed/29396403
http://dx.doi.org/10.1038/s41598-018-20460-8

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