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Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships
Fatty acid nitroalkene derivatives (NO(2)-FA) activate Nrf2-regulated antioxidant gene expression and inhibit NF-κB-dependent cytokine expression. To better define NO(2)-FA structure-function relationships, a series of 22 new chemical entities (NCEs) containing an electrophilic nitroalkene functiona...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797128/ https://www.ncbi.nlm.nih.gov/pubmed/29396403 http://dx.doi.org/10.1038/s41598-018-20460-8 |