Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine

Bioconversion is useful to produce optically pure enantiomers in the pharmaceutical industry, thereby avoiding problems with side reactions during organic synthesis processes. A short-chain dehydrogenase/reductase from Serratia marcescens BCRC 10948 (SmSDR) can stereoselectively convert 1-(3-hydroxy...

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Detalles Bibliográficos
Autores principales: Liu, Jai-Shin, Kuan, Yi-Chia, Tsou, Yu, Lin, Tung-Yueh, Hsu, Wen-Hwei, Yang, Ming-Te, Lin, Jong-Yih, Wang, Wen-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797133/
https://www.ncbi.nlm.nih.gov/pubmed/29396495
http://dx.doi.org/10.1038/s41598-018-19235-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797133/
https://www.ncbi.nlm.nih.gov/pubmed/29396495
http://dx.doi.org/10.1038/s41598-018-19235-y

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