Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO). Here we show that fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of HO in an accurate genetic mouse model of FOP (Acv...

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Detalles Bibliográficos
Autores principales: Lees-Shepard, John B., Yamamoto, Masakazu, Biswas, Arpita A., Stoessel, Sean J., Nicholas, Sarah-Anne E., Cogswell, Cathy A., Devarakonda, Parvathi M., Schneider, Michael J., Cummins, Samantha M., Legendre, Nicholas P., Yamamoto, Shoko, Kaartinen, Vesa, Hunter, Jeffrey W., Goldhamer, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797136/
https://www.ncbi.nlm.nih.gov/pubmed/29396429
http://dx.doi.org/10.1038/s41467-018-02872-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797136/
https://www.ncbi.nlm.nih.gov/pubmed/29396429
http://dx.doi.org/10.1038/s41467-018-02872-2

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