Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts

Most cases of early onset torsion dystonia (DYT1) are caused by a 3-base pair deletion in one allele of the TOR1A gene causing loss of a glutamate in torsinA, a luminal protein in the nuclear envelope. This dominantly inherited neurologic disease has reduced penetrance and no other medical manifesta...

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Detalles Bibliográficos
Autores principales: György, Bence, Cruz, Lilian, Yellen, David, Aufiero, Massimo, Alland, Isabel, Zhang, Xuan, Ericsson, Maria, Fraefel, Cornel, Li, Yu-Ching, Takeda, Shuko, Hyman, Bradley T., Breakefield, Xandra O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797141/
https://www.ncbi.nlm.nih.gov/pubmed/29396398
http://dx.doi.org/10.1038/s41598-018-19865-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797141/
https://www.ncbi.nlm.nih.gov/pubmed/29396398
http://dx.doi.org/10.1038/s41598-018-19865-2

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