Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody

Assisted Design of Antibody and Protein Therapeutics (ADAPT) is an affinity maturation platform interleaving predictions and testing that was previously validated on monoclonal antibodies (mAbs). This study expands the applicability of ADAPT to single-domain antibodies (sdAbs), a promising class of...

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Detalles Bibliográficos
Autores principales: Sulea, Traian, Hussack, Greg, Ryan, Shannon, Tanha, Jamshid, Purisima, Enrico O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797146/
https://www.ncbi.nlm.nih.gov/pubmed/29396522
http://dx.doi.org/10.1038/s41598-018-20599-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797146/
https://www.ncbi.nlm.nih.gov/pubmed/29396522
http://dx.doi.org/10.1038/s41598-018-20599-4

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