Cargando…

Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody

Assisted Design of Antibody and Protein Therapeutics (ADAPT) is an affinity maturation platform interleaving predictions and testing that was previously validated on monoclonal antibodies (mAbs). This study expands the applicability of ADAPT to single-domain antibodies (sdAbs), a promising class of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sulea, Traian, Hussack, Greg, Ryan, Shannon, Tanha, Jamshid, Purisima, Enrico O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797146/ https://www.ncbi.nlm.nih.gov/pubmed/29396522 http://dx.doi.org/10.1038/s41598-018-20599-4

Ejemplares similares

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives (†)
por: Hussack, Greg, et al.
Publicado: (2010)

An update on antibody-based immunotherapies for Clostridium difficile infection
por: Hussack, Greg, et al.
Publicado: (2016)

Neutralization of Clostridium difficile toxin B with V(H)H-Fc fusions targeting the delivery and CROPs domains
por: Hussack, Greg, et al.
Publicado: (2018)

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies
por: Henry, Kevin A., et al.
Publicado: (2016)

Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease
por: Kandalaft, Hiba, et al.
Publicado: (2015)

Assisted Design of Antibody and Protein Therapeutics (ADAPT)
por: Vivcharuk, Victor, et al.
Publicado: (2017)

Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs
por: Gaudreault, Francis, et al.
Publicado: (2022)

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability
por: Hussack, Greg, et al.
Publicado: (2011)

Multivalent Anchoring and Oriented Display of Single-Domain Antibodies on Cellulose
por: Hussack, Greg, et al.
Publicado: (2009)

Single-Domain Antibodies Represent Novel Alternatives to Monoclonal Antibodies as Targeting Agents against the Human Papillomavirus 16 E6 Protein
por: Togtema, Melissa, et al.
Publicado: (2019)

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Corrigendum: Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Solvated interaction energy: from small-molecule to antibody drug design
por: Purisima, Enrico O., et al.
Publicado: (2023)

An accurate TMT-based approach to quantify and model lysine susceptibility to conjugation via N-hydroxysuccinimide esters in a monoclonal antibody
por: Hill, Jennifer J., et al.
Publicado: (2018)

Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor
por: Yogi, Alvaro, et al.
Publicado: (2022)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries
por: Henry, Kevin A., et al.
Publicado: (2017)

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
por: Shen, Aimee, et al.
Publicado: (2011)

Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
por: Liu, Jinyu, et al.
Publicado: (2022)

126 An Optimized, Synthetic DNA Vaccine Encoding the Toxin A and Toxin B Receptor Binding Domains of Clostridium difficile Induces Protective Antibody Responses In Vivo
por: Kutzler, Michele
Publicado: (2014)

Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases
por: Bélanger, Kasandra, et al.
Publicado: (2019)

Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
por: Corbeil, Christopher R., et al.
Publicado: (2021)

Endogenous Serum IgG Antibodies to Clostridium difficile Toxin B Are Associated with Protection against C. difficile Infection Recurrence
por: Kelly, Ciaran P, et al.
Publicado: (2017)

Isolation and characterization of camelid single-domain antibodies against HER2
por: Hussack, Greg, et al.
Publicado: (2018)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Toxin B is essential for virulence of Clostridium difficile
por: Lyras, Dena, et al.
Publicado: (2009)

Binding symmetry and surface flexibility mediate antibody self-association
por: Schrag, Joseph D., et al.
Publicado: (2019)

Binary Toxin and Death after Clostridium difficile Infection
por: Bacci, Sabrina, et al.
Publicado: (2011)

Spore Formation and Toxin Production in Clostridium difficile Biofilms
por: Semenyuk, Ekaterina G., et al.
Publicado: (2014)

The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
por: Chen, Shuyi, et al.
Publicado: (2015)

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis
por: Martin-Verstraete, Isabelle, et al.
Publicado: (2016)

Structure of the full-length Clostridium difficile toxin B
por: Chen, Peng, et al.
Publicado: (2019)

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains
por: Beer, Lara-Antonia, et al.
Publicado: (2018)

Immunogenicity and Protection from Receptor-Binding Domains of Toxins as Potential Vaccine Candidates for Clostridium difficile
por: Luo, Deyan, et al.
Publicado: (2019)

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
por: Sulea, Traian, et al.
Publicado: (2019)

Succession in the Gut Microbiome following Antibiotic and Antibody Therapies for Clostridium difficile
por: Peterfreund, Gregory L., et al.
Publicado: (2012)

Isolation of recombinant antibodies directed against surface proteins of Clostridium difficile
por: Shirvan, Ali Nazari, et al.
Publicado: (2016)

Application of Antibody-Mediated Therapy for Treatment and Prevention of Clostridium difficile Infection
por: Förster, Beatrix, et al.
Publicado: (2018)

Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model
por: Cohen, Ocean R., et al.
Publicado: (2014)

Enhanced antibody-antigen structure prediction from molecular docking using AlphaFold2
por: Gaudreault, Francis, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bsrepfldh4gugv7cnjfdfpahab