Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitax...

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Detalles Bibliográficos
Autores principales: Zheng, Yiyan, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Wang, Ming, Masuda, Kenta, Carrami, Eli M., Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Yau, Christopher, Jiang, Dahai, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Knapp, Stefan, Gray, Nathanael S., Campo, Leticia, Myers, Kevin A., Dhar, Sunanda, Ferguson, David, Bast, Robert C., Sood, Anil K., von Delft, Frank, Ahmed, Ahmed Ashour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797184/
https://www.ncbi.nlm.nih.gov/pubmed/29396402
http://dx.doi.org/10.1038/s41467-017-02811-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797184/
https://www.ncbi.nlm.nih.gov/pubmed/29396402
http://dx.doi.org/10.1038/s41467-017-02811-7

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