Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

p53 mutations are frequently detected in malignant gastric cancers. However, the molecular mechanisms by which loss of p53 function promotes gastric cancer are not clear. We utilized Gan mice (K19-Wnt1/C2mE), which have functional p53 and develop intestinal-type gastric tumors, to investigate the ro...

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Detalles Bibliográficos
Autores principales: Ohtsuka, Junko, Oshima, Hiroko, Ezawa, Issei, Abe, Ryo, Oshima, Masanobu, Ohki, Rieko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797237/
https://www.ncbi.nlm.nih.gov/pubmed/29396430
http://dx.doi.org/10.1038/s41598-018-20572-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797237/
https://www.ncbi.nlm.nih.gov/pubmed/29396430
http://dx.doi.org/10.1038/s41598-018-20572-1

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