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Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers
p53 mutations are frequently detected in malignant gastric cancers. However, the molecular mechanisms by which loss of p53 function promotes gastric cancer are not clear. We utilized Gan mice (K19-Wnt1/C2mE), which have functional p53 and develop intestinal-type gastric tumors, to investigate the ro...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797237/ https://www.ncbi.nlm.nih.gov/pubmed/29396430 http://dx.doi.org/10.1038/s41598-018-20572-1 |