IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

BACKGROUND: The endoplasmic reticulum (ER) is responsible for the control of correct protein folding and protein function which is crucial for cell survival. However, under pathological conditions, such as hypoxia–ischemia (HI), there is an accumulation of unfolded proteins thereby triggering the un...

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Detalles Bibliográficos
Autores principales: Chen, Di, Dixon, Brandon J., Doycheva, Desislava M., Li, Bo, Zhang, Yang, Hu, Qin, He, Yue, Guo, Zongduo, Nowrangi, Derek, Flores, Jerry, Filippov, Valery, Zhang, John H., Tang, Jiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797348/
https://www.ncbi.nlm.nih.gov/pubmed/29394934
http://dx.doi.org/10.1186/s12974-018-1077-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797348/
https://www.ncbi.nlm.nih.gov/pubmed/29394934
http://dx.doi.org/10.1186/s12974-018-1077-9

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