Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

BACKGROUND: Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects. METHODS: We present an advanced mechanism-based and biophysically realistic qua...

Descripción completa

Detalles Bibliográficos
Autores principales: Geerts, Hugo, Spiros, Athan, Roberts, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797372/
https://www.ncbi.nlm.nih.gov/pubmed/29394903
http://dx.doi.org/10.1186/s13195-018-0343-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797372/
https://www.ncbi.nlm.nih.gov/pubmed/29394903
http://dx.doi.org/10.1186/s13195-018-0343-5

Ejemplares similares