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TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation

TANK-binding kinase 1 (TBK1) is an important serine/threonine-protein kinase that mediates phosphorylation and nuclear translocation of IRF3, which contributes to induction of type I interferons (IFNs) in the innate antiviral response. In mammals, TBK1 spliced isoform negatively regulates the virus-...

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Detalles Bibliográficos
Autores principales: Hu, Yi Wei, Zhang, Jie, Wu, Xiao Man, Cao, Lu, Nie, Pin, Chang, Ming Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797597/
https://www.ncbi.nlm.nih.gov/pubmed/29441066
http://dx.doi.org/10.3389/fimmu.2018.00084