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Structural Insights into the Osteopontin-Aptamer Complex by Molecular Dynamics Simulations
Osteopontin is an intrinsically disordered protein involved in tissue remodeling. As a biomarker for pathological hypertrophy and fibrosis, the protein is targeted by an RNA aptamer. In this work, we model the interactions between osteopontin and its aptamer, including mono- (Na(+)) and divalent (Mg...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797602/ https://www.ncbi.nlm.nih.gov/pubmed/29441346 http://dx.doi.org/10.3389/fchem.2018.00002 |