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Structural Insights into the Osteopontin-Aptamer Complex by Molecular Dynamics Simulations

Osteopontin is an intrinsically disordered protein involved in tissue remodeling. As a biomarker for pathological hypertrophy and fibrosis, the protein is targeted by an RNA aptamer. In this work, we model the interactions between osteopontin and its aptamer, including mono- (Na(+)) and divalent (Mg...

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Detalles Bibliográficos
Autores principales:	La Penna, Giovanni, Chelli, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797602/ https://www.ncbi.nlm.nih.gov/pubmed/29441346 http://dx.doi.org/10.3389/fchem.2018.00002

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