Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation

In rodents, low doses of CD28-specific superagonistic monoclonal antibodies (CD28 superagonists, CD28SA) selectively activate regulatory T cells (Treg). This observation has recently been extended to humans, suggesting an option for the treatment of autoimmune and inflammatory diseases. However, a m...

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Detalles Bibliográficos
Autores principales: Langenhorst, Daniela, Tabares, Paula, Gulde, Tobias, Becklund, Bryan R., Berr, Susanne, Surh, Charles D., Beyersdorf, Niklas, Hünig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797646/
https://www.ncbi.nlm.nih.gov/pubmed/29441059
http://dx.doi.org/10.3389/fimmu.2017.01985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797646/
https://www.ncbi.nlm.nih.gov/pubmed/29441059
http://dx.doi.org/10.3389/fimmu.2017.01985

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