Functional alteration of canine isocitrate dehydrogenase 2 (IDH2) via an R174K mutation

Gliomas are common intracranial neoplasias in dogs. However, the underlying pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 2 (IDH2) is often mutated in gliomas. Although almost human IDH2 mutations have been identified at the Arg172 codon, few studies have reported structu...

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Detalles Bibliográficos
Autores principales: KAWAKAMI, Shota, OCHIAI, Kazuhiko, KATO, Yuiko, MICHISHITA, Masaki, HIRAMA, Hinako, OBARA, Ryo, AZAKAMI, Daigo, WATANABE, Masami, OMI, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797864/
https://www.ncbi.nlm.nih.gov/pubmed/29162772
http://dx.doi.org/10.1292/jvms.17-0362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797864/
https://www.ncbi.nlm.nih.gov/pubmed/29162772
http://dx.doi.org/10.1292/jvms.17-0362

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