Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was...

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Detalles Bibliográficos
Autores principales: Lee, Byung Cheon, Lee, Hae Min, Kim, Sorah, Avanesov, Andrei S., Lee, Aro, Chun, Bok-Hwan, Vorbruggen, Gerd, Gladyshev, Vadim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798039/
https://www.ncbi.nlm.nih.gov/pubmed/29343716
http://dx.doi.org/10.1038/s41598-017-15090-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798039/
https://www.ncbi.nlm.nih.gov/pubmed/29343716
http://dx.doi.org/10.1038/s41598-017-15090-5

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