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Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner
Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was...
Autores principales: | Lee, Byung Cheon, Lee, Hae Min, Kim, Sorah, Avanesov, Andrei S., Lee, Aro, Chun, Bok-Hwan, Vorbruggen, Gerd, Gladyshev, Vadim N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798039/ https://www.ncbi.nlm.nih.gov/pubmed/29343716 http://dx.doi.org/10.1038/s41598-017-15090-5 |
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