Multiscale simulation of thrombus growth and vessel occlusion triggered by collagen/tissue factor using a data-driven model of combinatorial platelet signalling

During clotting under flow, platelets bind and activate on collagen and release autocrinic factors such as ADP and thromboxane, while tissue factor (TF) on the damaged wall leads to localized thrombin generation. Towards patient-specific simulation of thrombosis, a multiscale approach was developed...

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Detalles Bibliográficos
Autores principales: Lu, Yichen, Lee, Mei Yan, Zhu, Shu, Sinno, Talid, Diamond, Scott L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798174/
https://www.ncbi.nlm.nih.gov/pubmed/27672182
http://dx.doi.org/10.1093/imammb/dqw015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798174/
https://www.ncbi.nlm.nih.gov/pubmed/27672182
http://dx.doi.org/10.1093/imammb/dqw015

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