Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer

DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder...

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Detalles Bibliográficos
Autores principales: Abbosh, Philip H., Plimack, Elizabeth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798524/
https://www.ncbi.nlm.nih.gov/pubmed/29430503
http://dx.doi.org/10.3233/BLC-170129
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author Abbosh, Philip H.
Plimack, Elizabeth R.
author_facet Abbosh, Philip H.
Plimack, Elizabeth R.
author_sort Abbosh, Philip H.
collection PubMed
description DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents.
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spelling pubmed-57985242018-02-08 Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer Abbosh, Philip H. Plimack, Elizabeth R. Bladder Cancer Review DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents. IOS Press 2018-01-20 /pmc/articles/PMC5798524/ /pubmed/29430503 http://dx.doi.org/10.3233/BLC-170129 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Abbosh, Philip H.
Plimack, Elizabeth R.
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title_full Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title_fullStr Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title_full_unstemmed Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title_short Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer
title_sort molecular and clinical insights into the role and significance of mutated dna repair genes in bladder cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798524/
https://www.ncbi.nlm.nih.gov/pubmed/29430503
http://dx.doi.org/10.3233/BLC-170129
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