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Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)

Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and are postulated to play a role in innate antibacteria...

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Detalles Bibliográficos
Autores principales:	Li, Kelin, Vorkas, Charles K., Chaudhry, Ashutosh, Bell, Donielle L., Willis, Richard A., Rudensky, Alexander, Altman, John D., Glickman, Michael S., Aubé, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798775/ https://www.ncbi.nlm.nih.gov/pubmed/29401462 http://dx.doi.org/10.1371/journal.pone.0191837

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