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Enhancement of pharmacokinetic and pharmacological behavior of ocular dorzolamide after factorial optimization of self-assembled nanostructures

Dorzolamide hydrochloride is frequently administered for the control of the intra-ocular pressure associated with glaucoma. The aim of this study is to develop and optimize self-assembled nanostructures of dorzolamide hydrochloride and L-α-Phosphatidylcholine to improve the pharmacokinetic parameter...

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Detalles Bibliográficos
Autores principales: Afify, Enas A. M. R., Elsayed, Ibrahim, Gad, Mary K., Mohamed, Magdy I., Afify, Abd El-Moneim M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798776/
https://www.ncbi.nlm.nih.gov/pubmed/29401498
http://dx.doi.org/10.1371/journal.pone.0191415