HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in HPV-associated cancers. Integration is random, and each site is unique depending on how and where the virus integrates. We recently showed that tandemly integrated HPV16 could result in the formation of a super-en...

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Detalles Bibliográficos
Autores principales: Warburton, Alix, Redmond, Catherine J., Dooley, Katharine E., Fu, Haiqing, Gillison, Maura L., Akagi, Keiko, Symer, David E., Aladjem, Mirit I., McBride, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798845/
https://www.ncbi.nlm.nih.gov/pubmed/29364907
http://dx.doi.org/10.1371/journal.pgen.1007179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798845/
https://www.ncbi.nlm.nih.gov/pubmed/29364907
http://dx.doi.org/10.1371/journal.pgen.1007179

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