Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion

Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and deubiquitylases (DUBs). Here, we identify a new function of Cdc48 in ubiquitin-dependent regulation of mitochondrial dynamics. The DUBs Ubp12 and Ubp2 exert opposing effects on mitochondrial fusion and cleave dif...

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Detalles Bibliográficos
Autores principales: Simões, Tânia, Schuster, Ramona, den Brave, Fabian, Escobar-Henriques, Mafalda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798933/
https://www.ncbi.nlm.nih.gov/pubmed/29309037
http://dx.doi.org/10.7554/eLife.30015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798933/
https://www.ncbi.nlm.nih.gov/pubmed/29309037
http://dx.doi.org/10.7554/eLife.30015

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