Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

Yeast Ndi1 is a monotopic alternative NADH dehydrogenase. Its crystal structure in complex with the electron acceptor, ubiquinone, has been determined. However, there has been controversy regarding the ubiquinone binding site. To address these points, we identified the first competitive inhibitor of...

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Detalles Bibliográficos
Autores principales: Yamashita, Tetsuo, Inaoka, Daniel Ken, Shiba, Tomoo, Oohashi, Takumi, Iwata, So, Yagi, Takao, Kosaka, Hiroaki, Miyoshi, Hideto, Harada, Shigeharu, Kita, Kiyoshi, Hirano, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799168/
https://www.ncbi.nlm.nih.gov/pubmed/29402945
http://dx.doi.org/10.1038/s41598-018-20775-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799168/
https://www.ncbi.nlm.nih.gov/pubmed/29402945
http://dx.doi.org/10.1038/s41598-018-20775-6

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