Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence

The large expansion of GGGGCC (G4C2) repeats of the C9orf72 gene have been found to lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The structural polymorphisms of C9orf72 HRE DNA and RNA may cause aberrant transcr...

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Detalles Bibliográficos
Autores principales: Zhou, Bo, Geng, Yanyan, Liu, Changdong, Miao, Haitao, Ren, Yaguang, Xu, Naining, Shi, Xiao, You, Yingying, Lee, Tunglun, Zhu, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799222/
https://www.ncbi.nlm.nih.gov/pubmed/29402965
http://dx.doi.org/10.1038/s41598-018-20852-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799222/
https://www.ncbi.nlm.nih.gov/pubmed/29402965
http://dx.doi.org/10.1038/s41598-018-20852-w

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