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Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing

Affinity maturation is the process whereby the immune system generates antibodies of higher affinities during a response to antigen. It is unique in being the only evolutionary mechanism known to operate on a molecule in an organism’s own body. Deciphering the structural mechanisms through which som...

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Detalles Bibliográficos
Autores principales: Mishra, Arjun K., Mariuzza, Roy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799246/
https://www.ncbi.nlm.nih.gov/pubmed/29449843
http://dx.doi.org/10.3389/fimmu.2018.00117