Cargando…

Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster

Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olufs, Zachariah P. G., Loewen, Carin A., Ganetzky, Barry, Wassarman, David A., Perouansky, Misha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799260/ https://www.ncbi.nlm.nih.gov/pubmed/29402974 http://dx.doi.org/10.1038/s41598-018-20720-7

Ejemplares similares

Interactions among Genetic Background, Anesthetic Agent, and Oxygen Concentration Shape Blunt Traumatic Brain Injury Outcomes in Drosophila melanogaster
por: Scharenbrock, Amanda R., et al.
Publicado: (2020)

Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics
por: Borchardt, Luke A., et al.
Publicado: (2023)

Loss of the Antimicrobial Peptide Metchnikowin Protects Against Traumatic Brain Injury Outcomes in Drosophila melanogaster
por: Swanson, Laura C., et al.
Publicado: (2020)

Isoflurane Potentiation of GABA(A) Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation
por: Lor, Chong, et al.
Publicado: (2020)

A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila
por: Loewen, Carin, et al.
Publicado: (2018)

Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer’s disease (Review)
por: JIANG, JUE, et al.
Publicado: (2015)

Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila
por: Katzenberger, Rebeccah J., et al.
Publicado: (2016)

Sevoflurane Induces DNA Damage Whereas Isoflurane Leads to Higher Antioxidative Status in Anesthetized Rats
por: Rocha, Thalita L. A., et al.
Publicado: (2015)

Orexinergic innervations at GABAergic neurons of the lateral habenula mediates the anesthetic potency of sevoflurane
por: Zhou, Fang, et al.
Publicado: (2023)

Effects of blunt force injuries in third-instar Drosophila larvae persist through metamorphosis and reduce adult lifespan
por: Lika, Jorgo, et al.
Publicado: (2021)

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice
por: Zhao, Shiyi, et al.
Publicado: (2021)

The differential effects of isoflurane and sevoflurane on neonatal mice
por: Zhao, Shuai, et al.
Publicado: (2020)

Comparative evaluation of isoflurane and sevoflurane in avian patients
por: Anjana, R. R., et al.
Publicado: (2021)

Beta-blockers reduce intestinal permeability and early mortality following traumatic brain injury in Drosophila
por: Scharenbrock, Amanda R, et al.
Publicado: (2021)

Effects of inhaled anesthetics sevoflurane and isoflurane on lung morphofunction and biological markers in experimental pulmonary and extrapulmonary acute respiratory distress syndrome
por: Samary, CS, et al.
Publicado: (2015)

Isoflurane, sevoflurane and desflurane use in cane toads (Rhinella marina)
por: Morrison, Kaleigh E., et al.
Publicado: (2016)

Renal responses to sevoflurane and isoflurane in patients undergoing donor nephrectomy
por: Joob, Beuy, et al.
Publicado: (2018)

Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice
por: Yu, Qian, et al.
Publicado: (2020)

Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane
por: Eckenhoff, Roderic G., et al.
Publicado: (2009)

Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane-inhibited aggressiveness of hepatic carcinoma
por: Hu, Jing, et al.
Publicado: (2018)

Ketogenic diet reduces early mortality following traumatic brain injury in Drosophila via the PPARγ ortholog Eip75B
por: Blommer, Joseph, et al.
Publicado: (2021)

Phosphoproteome Profiling of SH-SY5y Neuroblastoma Cells Treated with Anesthetics: Sevoflurane and Isoflurane Affect the Phosphorylation of Proteins Involved in Cytoskeletal Regulation
por: Lee, Joomin, et al.
Publicado: (2016)

Randomized Comparison of Isoflurane versus Sevoflurane and Desflurane for Maintenance of Ambulatory Anesthesia
por: Kurhekar, Pranjali, et al.
Publicado: (2017)

Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?
por: Marquardt, Nicole, et al.
Publicado: (2018)

Antimicrobial effects of liquid anesthetic isoflurane on Candida albicans
por: Barodka, Viachaslau M, et al.
Publicado: (2006)

Mild Hypothermia Attenuates the Anesthetic Isoflurane-Induced Cytotoxicity
por: Li, Cheng, et al.
Publicado: (2017)

Hiccup-Like Response in a Dog Anesthetized with Isoflurane
por: Vettorato, Enzo, et al.
Publicado: (2016)

The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability
por: Ou, Mengchan, et al.
Publicado: (2019)

Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
por: Pypendop, Bruno H., et al.
Publicado: (2021)

Anesthesia with Isoflurane and Sevoflurane in the Crested Serpent Eagle (Spilornis cheela hoya): Minimum Anesthetic Concentration, Physiological Effects, Hematocrit, Plasma Chemistry and Behavioral Effects
por: CHAN, Fang-Tse, et al.
Publicado: (2013)

Performance of Surgical Stress Index during Sevoflurane-Fentanyl and Isoflurane-Fentanyl Anesthesia
por: Mustola, S., et al.
Publicado: (2010)

Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model
por: Kim, Stella P., et al.
Publicado: (2016)

Effects of isoflurane and sevoflurane alone and in combination with butorphanol or medetomidine on the bispectral index in chickens
por: Velasco Gallego, Maria Luisa, et al.
Publicado: (2021)

Autophagy promotes synapse development in Drosophila
por: Shen, Wei, et al.
Publicado: (2009)

Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster
por: Leung, Angus, et al.
Publicado: (2021)

Genes Encoding Drosophila melanogaster RNA Polymerase II General Transcription Factors: Diversity in Tfiia and Tfiid Components Contributes to Gene-Specific Transcriptional Regulation
por: Aoyagi, Norikazu, et al.
Publicado: (2000)

Binding of the general anesthetic sevoflurane to ion channels
por: Stock, Letícia, et al.
Publicado: (2018)

The effect of desflurane, isoflurane and sevoflurane on the hemoglobin oxygen dissociation curve in human blood samples
por: Ronzani, Marco, et al.
Publicado: (2022)

Validation of the bispectral index as an indicator of anesthetic depth in Thoroughbred horses anesthetized with sevoflurane
por: TOKUSHIGE, Hirotaka, et al.
Publicado: (2016)

A neuropeptide signaling pathway regulates synaptic growth in Drosophila
por: Chen, Xu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_i9vrlqn33nrse8lh5n16jf1stk