Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP...

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Detalles Bibliográficos
Autores principales: Wiley, Christopher D., Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V., Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R., Campisi, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799282/
https://www.ncbi.nlm.nih.gov/pubmed/29402901
http://dx.doi.org/10.1038/s41598-018-20000-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799282/
https://www.ncbi.nlm.nih.gov/pubmed/29402901
http://dx.doi.org/10.1038/s41598-018-20000-4

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